Santa Clara is located in the central part of Cuba, about 4 hours drive from Havana. The town is the capital of the Cuban province of Villa Clara. With a population near a quarter million, Santa Clara is the 5th largest Cuban city by population. Santa Clara's Attractions Che Guevara Memorial Complex Santa Clara's major landmark is the Che Guevara Memorial Complex . The town is well known for its connection to Cuba's revolutionary history. It was here where Che’s rebel army de